P cadherin (CDH3) Rabbit Polyclonal Antibody

CAT#: TA302124

Rabbit Polyclonal Antibody against CDH3 (C-term)

Product Images

Western blot analysis of anti-CDH3 Antibody (C-term) (Cat.#TA302124) in K562 cell line lysates (35ug/lane). CDH3 (arrow) was detected using the purified Pab.

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  Figure from citation: Western Blot of CDH3 protein level by using anti-CDH3 antibody in CRC patient sera. View Citation

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  Figure from citation: ELISA of CDH3 protein level by using anti-CDH3 antibody in CRC patient sera. Humanhttp://www.ncbi.nlm.nih.gov/pubmed/23682078Human

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  Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with CDH3 antibody (C-term) (Cat.#TA302124), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 1:1000, IHC: 1:10~50
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This CDH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 660-688 amino acids from the C-terminal region of human CDH3.
• Formulation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 91418 Da
• Gene Name: cadherin 3
• Database Link:
  NP_001784
  Entrez Gene 1001 Human
  UniProt ID P22223
• Background: CDH3 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in the gene encoding CDH3 have been associated with congential hypotrichosis with juvenile macular dystrophy.
• Synonyms: CDHP; HJMD; PCAD

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)