PYGM Rabbit Polyclonal Antibody

CAT#: TA302172

Rabbit Polyclonal Antibody against PYGM (C-term)

Product Images

Western blot analysis of PYGM (arrow) using rabbit polyclonal PYGM Antibody (C-term) (Cat.#TA302172). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PYGM gene (Lane 2) (Origene Technologies).

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  Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with PYGM antibody (C-term) (Cat.#TA302172), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000, IHC: 1:10~50
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This PYGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 698-727 amino acids from the C-terminal region of human PYGM.
• Formulation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Concentration: lot specific
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 97092 Da
• Gene Name: phosphorylase, glycogen, muscle
• Database Link:
  NP_005600
  Entrez Gene 717451 MonkeyEntrez Gene 5837 Human
  UniProt ID P11217
• Background: PYGM catalyzes and regulates the breakdown of glycogen to glucose-1-phosphate. Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5), also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.
• Synonyms: glycogen; glycogen phosphorylase; glycogen storage disease type V; glycogen storage disease type V); McArdle syndrome; muscle; muscle (McArdle syndrome; myophosphorylase; phosphorylase

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Insulin signaling pathway, Starch and sucrose metabolism