GCN2 (EIF2AK4) Rabbit Polyclonal Antibody

CAT#: TA302175

Rabbit Polyclonal Antibody against EIF2AK4 (N-term G11)

Product Images

Western blot analysis of GCN2 (arrow) using GCN2 Antibody (N-term G11) (Cat.#TA302175). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GCN2 gene (Lane 2) (Origene Technologies).

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  Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000, IHC: 1:50~100
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This GCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GCN2.
• Formulation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 186838 Da
• Gene Name: eukaryotic translation initiation factor 2 alpha kinase 4
• Database Link:
  NP_001013725
  Entrez Gene 440275 Human
  UniProt ID Q9P2K8
• Background: GCN2 (EIF2AK4) belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses.
• Synonyms: GCN2; PVOD2

Reference Data

• Protein Families: Druggable Genome, Protein Kinase