MVP Rabbit Polyclonal Antibody

CAT#: TA302181

Rabbit Polyclonal Antibody against MVP (C-term)

Product Images

The anti-MVP C-term Antibody (Cat.#TA302181) is used in Western blot to detect MVP in A375 lysate.

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  Western blot analysis of MVP (arrow) using rabbit polyclonal MVP C-term Antibody (Cat.#TA302181). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MVP gene (Lane 2) (Origene Technologies).

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  Formalin-fixed and paraffin-embedded human lung carcinoma with MVP Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

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  Flow cytometric analysis of NCI-H292 cells using MVP Antibody (C-term) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: WB: 1:1000, IHC: 1:10~50, FC: 1:10~50
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This MVP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 863-893 amino acids from the C-terminal region of human MVP.
• Formulation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Concentration: lot specific
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 99327 Da
• Gene Name: major vault protein
• Database Link:
  NP_059447
  Entrez Gene 9961 Human
  UniProt ID Q14764
• Background: MVP, the major vault protein, is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance.
• Synonyms: LRP; VAULT1

Reference Data

• Protein Families: Druggable Genome