TRPM8 Rabbit Polyclonal Antibody

CAT#: TA302224

Rabbit Polyclonal Antibody against TRPM8 (C-term C940)

Product Images

Western blot analysis of TRPM8 (arrow) using rabbit polyclonal TRPM8 Antibody (C-term C940) (Cat.#TA302224).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TRPM8 gene (Lane 2) (Origene Technologies).

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  Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with TRPM8 antibody (C-term C940) (Cat.#TA302224), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000, IHC: 1:10~50
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This TRPM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 926-956 amino acids from the C-terminal region of human TRPM8.
• Formulation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Concentration: lot specific
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 127685 Da
• Gene Name: transient receptor potential cation channel subfamily M member 8
• Database Link:
  NP_076985
  Entrez Gene 171382 MouseEntrez Gene 79054 Human
  UniProt ID Q7Z2W7
• Background: TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. It is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium.
• Synonyms: LTRPC6; TRPP8

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane