CRKL Rabbit Monoclonal Antibody [Clone ID: EP270Y]

CAT#: TA303464

Rabbit monoclonal antibody against Phospho CrkL (pY207)(EP270Y) (phospho-specific)

Product Images

Western blot - CrkL antibody [EP270Y]; All lanes : Anti-CrkL (phospho Y207) antibody [EP270Y] at 1/50000 dilution.Lane 1 : (A) K562 cell lysates untreated.Lane 2 : (B) K562 cell lysates treated with AP.Lysates/proteins at 10 ug per lane.Predicted band size : 34 kDa.Observed band size : 37 kDa.

Specifications

Product Data

• Clone Name: EP270Y
• Applications: WB
• Recommended Dilution: WB: 1:50000; IP: 1:50
• Reactivities: Human, Mouse
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr207 of human CrkL was used as immunogen. The antibody only detects CrkL phosphorylated on Tyrosine 207.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: v-crk avian sarcoma virus CT10 oncogene homolog-like
• Database Link:
  NP_005198
  Entrez Gene 12929 MouseEntrez Gene 287942 RatEntrez Gene 1399 Human
  UniProt ID P46109
• Background: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
• Synonyms: v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like
• Note: Is unsuitable for Flow Cyt or IHC-P.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Chemokine signaling pathway, Chronic myeloid leukemia, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton, Renal cell carcinoma