Ubiquitin (UBB) Rabbit Monoclonal Antibody [Clone ID: EP296YT]

CAT#: TA303818

Rabbit monoclonal antibody against Ubiquitin (C-term)(EP296YT)

Product Images

Western blot - Ubiquitin antibody [EP296YT]; Anti-Ubiquitin antibody [EP296YT] at 1/2000 dilution + Hela cell lysate.Predicted band size : 8 kDa.Observed band size : 8.5 kDa.

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Ubiquitin antibody [EP296YT]; TA303818 at a 1:250 dilution staining Ubiquitin in human prostate adenocarcinoma using Immunohistochemistry, Paraffin Embedded Tissue.

Specifications

Product Data

• Clone Name: EP296YT
• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues in the C-term of human Ubiquitin was used as immunogen.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 8 kDa
• Gene Name: ubiquitin B
• Database Link:
  NP_061828
  Entrez Gene 22187 MouseEntrez Gene 192255 RatEntrez Gene 7314 Human
  UniProt ID P0CG47
• Background: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
• Synonyms: HEL-S-50
• Note: Is unsuitable for Flow Cyt,ICC/IF or IP.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Parkinson's disease