DOK1 Rabbit Polyclonal Antibody

CAT#: TA305939

Rabbit Polyclonal DOK1 Antibody

Product Images

Western blot analysis of DOK1 in Jurkat (Jur) and THP-1 (THP) cell lysates with DOK1 antibody at 1 ug/mL.

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  Immunocytochemistry of DOK1 in K562 cells with DOK1 antibody at 2 ug/mL.

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  Immunofluorescence of DOK1 in K562 cells with DOK1 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 10 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DOK1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DOK1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: docking protein 1
• Database Link:
  NP_001372
  Entrez Gene 1796 Human
  UniProt ID Q99704
• Background: Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP). p62dok represents a new family with very recently identified p56dok.
• Synonyms: P62DOK

Reference Data

• Protein Families: Druggable Genome