SIRP alpha (SIRPA) Rabbit Polyclonal Antibody

CAT#: TA305948

Rabbit Polyclonal SIRP alpha Antibody

Product Images

Western blot analysis of SIRP alpha in THP-1 whole cell lysate with SIRP alpha antibody at 1:2000 dilution.

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  Immunocytochemistry of SIRP alpha in THP-1 cells with SIRP alpha antibody at 1 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SIRP alpha antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human SIRP alpha 1? The sequences of the immunogenic peptide differ from those of mouse, rat and bovine by one amino acid.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Antibody is DEAE purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: signal regulatory protein alpha
• Database Link:
  NP_001035111
  Entrez Gene 19261 MouseEntrez Gene 25528 RatEntrez Gene 140885 Human
  UniProt ID P78324
• Background: Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.
• Synonyms: BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Transmembrane