GDNF Receptor alpha 1 (GFRA1) Rabbit Polyclonal Antibody

CAT#: TA305952

Rabbit Polyclonal GFR alpha 1 Antibody

Product Images

Western blot analysis of GFR alpha 1 in crude membrane fractions of human brain (B), liver (L), kidney (K), and spleen (S), respectively, with GFR alpha 1 antibody at 1ug/ml.

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  Immunohistochemistry of GFR alpha 1 in human brain tissue with GFR alpha 1 antibody at 1ug/ml.

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  Immunohistochemistry of GFR alpha 1 in human brain tissue with GFR alpha 1 antibody at 2.5ug/ml.

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  Immunofluorescence of GFR alpha 1 in human brain tissue with GFR alpha 1 antibody at 20ug/ml.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, IHC: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GFR alpha 1 antibody was raised against a 14 amino acid peptide near the center of human GFR alpha 1. The immunogen is located within amino acids 360 - 410 of GFR alpha 1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Antibody is DEAE purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: GDNF family receptor alpha 1
• Database Link:
  NP_001138925
  Entrez Gene 14585 MouseEntrez Gene 25454 RatEntrez Gene 2674 Human
  UniProt ID P56159
• Background: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently. GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
• Synonyms: GDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1

Reference Data

• Protein Families: Druggable Genome