DR5 (TNFRSF10B) Rabbit Polyclonal Antibody

CAT#: TA305974

Rabbit Polyclonal DR5 Antibody

Product Images

Western blot analysis of DR5 in HeLa (H) and K562 (K) cell lysates with DR5 antibody at 2ug/ml.

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  Immunohistochemistry of DR5 in mouse kidney tissue with DR5 Antibody at 5ug/ml.

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  Immunofluorescence of DR5 in HeLa cells with DR5 antibody at 20ug/ml.

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  Immunofluorescence of DR5 in mouse kidney tissue with DR5 Antibody at 20ug/ml.

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  Immunocytochemistry of DR5 in HeLa cells with DR5 antibody at 5ug/ml.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 2 ug/mL, ICC: 5 ug/mL, IF: 10 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DR5 antibody was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of human DR5 precursor. The immunogen is located within the last 50 amino acids of DR5.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor receptor superfamily member 10b
• Database Link:
  NP_003833
  Entrez Gene 21933 MouseEntrez Gene 8795 Human
  UniProt ID O14763
• Background: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-7). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kappaB.
• Synonyms: CD262; DR5; KILLER; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity, p53 signaling pathway