Apoptosis repressor with CARD (NOL3) Rabbit Polyclonal Antibody

CAT#: TA305985

Rabbit Polyclonal ARC Antibody

Product Images

Western blot analysis of ARC in HeLa (H), KB (K), and A549 (A) whole cell lysates with ARC antibody at 1:1000 dilution. 1st Below: Immunohistochemistry of ARC in human heart tissue at 5 ug/ml. 2nd Below: Immunohistochemistry of ARC in human skeletal muscle with ARC antibody at 5 ug/ml.

• 

  Immunohistochemistry of ARC in human skeletal muscle with ARC antibody at 5 ug/ml.

• 

  Immunohistochemistry of ARC in human heart tissue with ARC antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ARC antibody was raised against a peptide corresponding to amino acids 191 to 208 of human origin.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: nucleolar protein 3
• Database Link:
  NP_003937
  Entrez Gene 8996 Human
  UniProt ID O60936
• Background: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).
• Synonyms: ARC; FCM; MYP; NOP; NOP30