Amyloid Precursor Protein (APP) Rabbit Polyclonal Antibody

CAT#: TA306003

Rabbit Polyclonal APP Antibody

Product Images

Western blot analysis of APP in mouse (M) and rat (R) brain tissue lysates with APP antibody at 2 ug/ml.

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  Immunohistochemical staining of rat brain using APP antibody at 2 ug/ml.

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  Immunofluorescence of APP in Rat Brain cells with APP antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 2 ug/mL, IHC: 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: APP antibody was raised against a peptide corresponding to amino acids 737 to 751 of human amyloid A4 protein precursor (APP) or 85 to 99 of the C99 fragment generated by b-secretase cleavage. The peptide sequences are identical to those of monkey, mouse, rat, chicken, and a variety of other species .
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: amyloid beta precursor protein
• Database Link:
  NP_000475
  Entrez Gene 11820 MouseEntrez Gene 54226 RatEntrez Gene 351 Human
  UniProt ID P05067
• Background: Accumulation of the amyloid-beta peptide (alphabeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The b-amyloid protein precursor (APP) is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-beta peptide (alphabeta), which is deposited in the brains of all suffers of Alzheimer’s disease.
• Synonyms: AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Alzheimer's disease