Apoptosis repressor with CARD (NOL3) Rabbit Polyclonal Antibody

CAT#: TA306014

Rabbit Polyclonal ARC Antibody

Product Images

Western blot analysis of ARC in HeLa whole cell lysates with ARC antibody at 1:500 dilution.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ARC antibody was raised against a peptide corresponding to amino acids 2 to 18 of human origin. These sequences are identical to those of human nuclear protein Nop30 (2) and differ from those of the rat homolog of ARC by one amino acid (3).
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: nucleolar protein 3
• Database Link:
  NP_003937
  Entrez Gene 78688 MouseEntrez Gene 85383 RatEntrez Gene 8996 Human
  UniProt ID O60936
• Background: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK BCL10, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).
• Synonyms: ARC; FCM; MYP; NOP; NOP30