IRAKM (IRAK3) Rabbit Polyclonal Antibody

CAT#: TA306061

Rabbit Polyclonal IRAK-M Antibody

Product Images

Western blot analysis of IRAK-M in (M) mouse spleen and (R) rat liver tissue lysates with IRAK-M antibody at 1ug/ml.

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  Immunohistochemical staining of rat liver tissue using IRAK-M antibody at 2ug/ml.

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  Immunohistochemistry of IRAK-M in human spleen tissue with IRAK-M antibody at 5ug/ml.

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  Immunofluorescence of IRAK-M in Rat Liver tissue with IRAK-M antibody at 10ug/ml.

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  Immunofluorescence of IRAK2 in A20 cells with IRAK2 antibody at 20ug/ml.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, IHC: 2 ug/mL, IF: 10 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IRAK-M antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IRAK-M. The immunogen is located within the last 50 amino acids of IRAK-M.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 1 receptor associated kinase 3
• Database Link:
  NP_009130
  Entrez Gene 73914 MouseEntrez Gene 314870 RatEntrez Gene 11213 Human
  UniProt ID Q9Y616
• Background: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors (1,2), which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M (3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.
• Synonyms: ASRT5; IRAKM

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Apoptosis, Neurotrophin signaling pathway