TACI (TNFRSF13B) Rabbit Polyclonal Antibody

CAT#: TA306064

Rabbit Polyclonal TACI Antibody

Product Images

Western blot analysis of TACI in K562 (A) and U937 (B) cell lysates with TACI antibody at 5 ug/mL.

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  Immunocytochemistry of TACI in K562 cells with TACI antibody at 2 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 5 ug/mL, ICC: 2 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TACI antibody was raised against a synthetic peptide mapping at the amino terminus of human TACI .
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor receptor superfamily member 13B
• Database Link:
  NP_036584
  Entrez Gene 23495 Human
  UniProt ID O14836
• Background: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 (1-4) and April/TALL-2, respectively, (3,5). BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified (6,7). TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
• Synonyms: CD267; CVID; CVID2; IGAD2; RYZN; TACI; TNFRSF14B

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Primary immunodeficiency