APRIL (TNFSF13) Rabbit Polyclonal Antibody

CAT#: TA306069

Rabbit Polyclonal APRIL Antibody

Product Images

Western blot analysis of APRIL expression in Jurkat cells with APRIL antibody at 1 ug/ml (A), 2 ug/ml (B), and 4 ug/ml (C).

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  Immunohistochemistry of APRIL in human prostate tissue with APRIL antibody at 10 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 4 ug/mL, ICC: 10 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: APRIL antibody was raised against a synthetic peptide corresponding to amino acids within a extracellular domain of human APRIL.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor superfamily member 13
• Database Link:
  NP_003799
  Entrez Gene 69583 MouseEntrez Gene 8741 Human
  UniProt ID O75888
• Background: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1a (for TNF related death ligand 1a) in human and mouse (1-4). Two receptors for APRIL were recently identified and designated TACI and BCMA (5-7). APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kappaB, and induces cell death (1-7). APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer (8,9).
• Synonyms: APRIL; CD256; PRO715; TALL-2; TALL2; TNLG7B; TRDL-1; UNQ383; ZTNF2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction