TEM8 (ANTXR1) Rabbit Polyclonal Antibody

CAT#: TA306121

Rabbit Polyclonal ATR Antibody

Product Images

Western blot analysis of ATR in HepG2 cell lysates with ATR antibody (IN) at (A) 0.5, (B) 1, and (C) 2 ug/ml.

• 

  Immunohistochemical staining of human brain tissue using ATR antibody at 2 ug/ml.

• 

  Immunofluorescence of ATR in Human Brain tissue with ATR antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ATR antibody was raised against a peptide corresponding to 13 amino acids near the center of human ATR.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Ion exchange chromatography purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: anthrax toxin receptor 1
• Database Link:
  NP_060623
  Entrez Gene 69538 MouseEntrez Gene 362393 RatEntrez Gene 84168 Human
  UniProt ID Q9H6X2
• Background: The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8) (1). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin (2). Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF) (3). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis (4).
• Synonyms: ATR; GAPO; TEM8

Reference Data

• Protein Families: Druggable Genome, Transmembrane