TLR2 Rabbit Polyclonal Antibody

CAT#: TA306125

Rabbit Polyclonal TLR2 Antibody

Product Images

Western blot analysis of TLR2 in A20 cell lysates with TLR2 antibody at 1 ug/ml in the presence (A) and absence (B) of its blocking peptide.

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  Immunohistochemical staining of human spleen cells using TLR2 antibody at 2 ug/ml.

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  Immunofluorescence of TLR2 in Human Spleen tissue with TLR2 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, IHC: 2 ug/mL, IF: 10 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TLR2 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human TLR2.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Ion exchange chromatography purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor 2
• Database Link:
  NP_003255
  Entrez Gene 24088 MouseEntrez Gene 7097 Human
  UniProt ID O60603
• Background: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappaB (4-6). TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer can recognize a variety of bacterial and mycoplasma lipoproteins respectively (reviewed in 7).
• Synonyms: CD282; TIL4

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway