Caspase 12 (CASP12) Rabbit Polyclonal Antibody

CAT#: TA306141

Rabbit Polyclonal Caspase-12 Antibody (Small)

Product Images

Western blot analysis of caspase-12 in mouse (lane A) and rat (lane B) liver lysate with caspase-12 antibody (small) at 1 ug/ml.

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  Immunohistochemical staining of human liver tissue using caspase-12 antibody at 10 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: caspase-12 antibody was raised against a synthetic peptide corresponding to amino acids within the small cleavage product of murine caspase-12.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: caspase 12 (gene/pseudogene)
• Database Link:
  NP_001177945
  Entrez Gene 12364 MouseEntrez Gene 156117 RatEntrez Gene 100506742 Human
  UniProt ID Q6UXS9
• Background: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including ϒ-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues (1).
• Synonyms: CASP-12; CASP12P1