ALS2CR2 (STRADB) Rabbit Polyclonal Antibody

CAT#: TA306142

Rabbit Polyclonal ILPIP Antibody

Product Images

Western blot analysis of ILPIP in human brain lysate with ILPIP antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of ILPIP in human brain tissue with ILPIP antibody at 10 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 10 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ILPIP antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ILPIP.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: STE20-related kinase adaptor beta
• Database Link:
  NP_061041
  Entrez Gene 227154 MouseEntrez Gene 501146 RatEntrez Gene 55437 Human
  UniProt ID Q9C0K7
• Background: ILPIP (ILP-interacting protein) has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family (1). Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1? converting enzyme of Fas-induced apotosis (1,2). This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival (3), suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.
• Synonyms: ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK; PRO1038

Reference Data

• Protein Families: Druggable Genome, Protein Kinase