ACE2 Rabbit Polyclonal Antibody (Angiotensin Converting Enzyme 2)

CAT#: TA306147

Rabbit Polyclonal ACE2 Antibody

Product Images

Western blot analysis of ACE2 in human kidney lysate with ACE2 antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/ml, respectively.

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  Immunohistochemical staining of human kidney tissue using ACE2 antibody at 2 ug/mL

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  Immunofluorescence of ACE2 in Human Kidney tissue with ACE2 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: angiotensin I converting enzyme 2
• Database Link:
  NP_068576
  Entrez Gene 59272 Human
  UniProt ID Q9BYF1
• Background: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology (1-2). In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus (3). The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function (4).
• Synonyms: ACEH

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Renin-angiotensin system