TLR7 Rabbit Polyclonal Antibody

CAT#: TA306156

Rabbit Polyclonal TLR7 Antibody

Product Images

Western blot analysis of TLR7 in Daudi cell lysates with TLR7 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.

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  Immunocytochemistry staining of Daudi cells using TLR7 antibody at 2 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TLR7 antibody was raised against a peptide corresponding to 14 amino acids near the middle of mouse TLR7.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Ion exchange chromatography purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor 7
• Database Link:
  NP_057646
  Entrez Gene 170743 MouseEntrez Gene 51284 Human
  UniProt ID Q9NYK1
• Background: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR7, like TLRs 3, 8, and 9, is localized in intracellular acidic compartments such as the phagolysosome (6) and will recognize some single-stranded RNA viruses such as vesicular stomatitis virus (VSV) and influenza virus (7). Activation of TLR7 by VSV results in stimulation of the immune response including IFNΑ secretion, suggesting the importance of TLR7 in virus recognition.
• Synonyms: TLR7-like

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway