MD2 (LY96) Rabbit Polyclonal Antibody

CAT#: TA306161

Rabbit Polyclonal MD-2 Antibody

Product Images

Western blot analysis of MD-2 in mouse spleen cell lysate with MD-2 antibody at 1ug/ml.

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  Immunohistochemical staining of rat spleen cells using MD-2 antibody at 2ug/ml.

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  Immunohistochemistry of MD-2 in human spleen tissue with MD-2 antibody at 2.5ug/ml.

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  Immunofluorescence of MD-2 in Rat Spleen tissue with MD-2 antibody at 10ug/ml.

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  Immunofluorescence of MD-2 in human spleen tissue with MD 2 antibody at 20ug/ml.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: MD-2 antibody was raised against a peptide corresponding to 13 amino acids near the center of human MD-2. The immunogen is located within the last 50 amino acids of MD-2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Ion exchange chromatography purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: lymphocyte antigen 96
• Database Link:
  NP_056179
  Entrez Gene 17087 MouseEntrez Gene 448830 RatEntrez Gene 23643 Human
  UniProt ID Q9Y6Y9
• Background: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2; e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).
• Synonyms: ESOP-1; ly-96; MD-2; MD2

Reference Data

• Protein Families: Secreted Protein
• Protein Pathways: Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway