BAX Rabbit Polyclonal Antibody

CAT#: TA306176

Rabbit Polyclonal Bax Antibody


USD 430.00

5 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1 - 4 ug/mL, ICC: 2 ug/mL, IF: 2 ug/mL
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Bax antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Bax.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Ion exchange chromatography purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name BCL2 associated X protein
Background Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli (4,5). It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability (6,7).
Synonyms BCL2L4
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Huntington's disease, Neurotrophin signaling pathway, p53 signaling pathway, Pathways in cancer, Prion diseases

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.