NADE (BEX3) Rabbit Polyclonal Antibody

CAT#: TA306179

Rabbit Polyclonal NADE Antibody

Product Images

Western blot analysis of NADE in Human brain cell lysates with NADE antibody at 1 ug/ml in the presence (A) or absence (B) of blocking peptide.

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  Immunohistochemistry of NADE in human brain tissue with NADE antibody at 2 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Ion exchange chromatography purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: brain expressed X-linked 3
• Database Link:
  NP_055195
  Entrez Gene 12070 MouseEntrez Gene 27018 Human
  UniProt ID Q00994
• Background: The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR (2). Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed (5). Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells (3), NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage (4).
• Synonyms: Bex; DXS6984E; HGR74; NADE; NGFRAP1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Neurotrophin signaling pathway