SIGIRR Rabbit Polyclonal Antibody

CAT#: TA306181

Rabbit Polyclonal SIGIRR Antibody

Product Images

Western blot analysis of SIGIRR expression in (A) A549 and (B) MCF7 cell lysate with SIGIRR antibody at 1ug/ml.

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  Immunocytochemistry of SIGIRR in A549 cells with SIGIRR antibody at 10ug/ml.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 10 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. The immunogen is located within the last 50 amino acids of SIGIRR.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
• Database Link:
  NP_001128525
  Entrez Gene 24058 MouseEntrez Gene 59307 Human
  UniProt ID Q6IA17
• Background: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family (3). Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling (4,5). However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion (4).
• Synonyms: IL-1R8; TIR8

Reference Data

• Protein Families: Transcription Factors, Transmembrane