Caspase 4 (CASP4) Rabbit Polyclonal Antibody

CAT#: TA306196

Rabbit Polyclonal Caspase-4 Antibody

Product Images

Western blot analysis of caspase-4 in human spleen cells with caspase-4 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemical staining of human spleen tissue using caspase-4 antibody at 2 ug/ml.

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  Immunofluorescence of Caspase-4 in A20 cells with Caspase-4 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Caspase-4 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-4.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: caspase 4
• Database Link:
  NP_001216
  Entrez Gene 837 Human
  UniProt ID P49662
• Background: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer’s disease (5).
• Synonyms: ICE(rel)II; ICEREL-II; ICH-2; Mih1; TX

Reference Data

• Protein Families: Druggable Genome, Protease