Caspase 5 (CASP5) Rabbit Polyclonal Antibody
Other products for "CASP5"
Specifications
Product Data | |
Applications | IF, WB |
Recommended Dilution | WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 2 ug/mL |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Caspase-5 antibody was raised against a 14 amino acid peptide from the center of human Caspase-5. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | Affinity chromatography purified via peptide column |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | caspase 5 |
Database Link | |
Background | Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1beta (4). Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-ϒ (5). |
Synonyms | ICE(rel)III; ICEREL-III; ICH-3 |
Reference Data | |
Protein Families | Druggable Genome, Protease |
Protein Pathways | NOD-like receptor signaling pathway |
Documents
Product Manuals |
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