MCL1 Rabbit Polyclonal Antibody

CAT#: TA306209

Rabbit Polyclonal Mcl-1 Antibody


USD 430.00

5 Days*

Size
    • 100 ug

Product Images

Other products for "MCL1"

Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 0.5 - 2 ug/mL, ICC: 10 ug/mL
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Mcl-1 antibody was raised against a peptide corresponding to 16 amino acids near the center of human Mcl-1.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Ion exchange chromatography purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name myeloid cell leukemia 1
Background Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival (reviewed in 1). While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak (2,3). Mcl-1 was originally identified in differentiating myeloid cells (4), but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals (3). Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death (6).
Synonyms bcl2-L-3; BCL2L3; EAT; Mcl-1; mcl1; MCL1-ES; MCL1L; MCL1S; TM
Reference Data
Protein Families Druggable Genome, Transmembrane

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.