MCL1 Rabbit Polyclonal Antibody

CAT#: TA306209

Rabbit Polyclonal Mcl-1 Antibody

Product Images

Western blot analysis of Mcl-1 in Raji cell lysates with Mcl-1 antibody (IN) at (A) 0.5, (B) 1, and (C) 2 ug/mL.

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  Immunocytochemistry of Mcl-1 in Raji cells with Mcl-1 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 10 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Mcl-1 antibody was raised against a peptide corresponding to 16 amino acids near the center of human Mcl-1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Ion exchange chromatography purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: myeloid cell leukemia 1
• Database Link:
  NP_068779
  Entrez Gene 4170 Human
  UniProt ID Q07820
• Background: Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival (reviewed in 1). While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak (2,3). Mcl-1 was originally identified in differentiating myeloid cells (4), but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals (3). Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death (6).
• Synonyms: bcl2-L-3; BCL2L3; EAT; Mcl-1; mcl1; MCL1-ES; MCL1L; MCL1S; TM

Reference Data

• Protein Families: Druggable Genome, Transmembrane