CRMP1 Rabbit Polyclonal Antibody

CAT#: TA306259

Rabbit Polyclonal CRMP1 Antibody


USD 430.00

In Stock*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen CRMP1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human CRMP1.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name collapsin response mediator protein 1
Background Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis (1). Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity (2). CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain (3); later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth (4). CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons (5).
Synonyms CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3
Reference Data

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