TLR1 Rabbit Polyclonal Antibody

CAT#: TA306266

Rabbit Polyclonal TLR1 Antibody

Product Images

Western blot analysis of TLR1 in Daudi cell lysate with TLR1 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunocytochemistry of TLR1 in Daudi with TLR1 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 10 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TLR1 antibody was raised against a peptide corresponding to 17 amino acids near the center of human TLR1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Ion exchange chromatography purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor 1
• Database Link:
  NP_003254
  Entrez Gene 7096 Human
  UniProt ID Q15399
• Background: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5) so the organism can respond to potential infection. TLR1 is co-expressed with TLR2 on myeloid cells of the innate immune systems in lymphoid tissue such as monocytes and dendritic cells (6) where they form heterodimers that can recognize triacylated lipoproteins (7).
• Synonyms: CD281; rsc786; TIL; TIL. LPRS5

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway