TNFRSF14 Rabbit Polyclonal Antibody

CAT#: TA306306

Rabbit Polyclonal TNFRSF14 Antibody

Product Images

Western blot analysis of TNFRSF14 in Raji cell lysate with TNFRSF14 antibody at 2 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunocytochemistry of TNFRSF14 in Raji with TNFRSF14 antibody at 10 ug/mL.

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  Immunofluorescence of TNFRSF14 in Raji cells with TNFRSF14 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TNFRSF14 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human TNFRSF14.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor receptor superfamily member 14
• Database Link:
  NP_003811
  Entrez Gene 8764 Human
  UniProt ID Q92956
• Background: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-kappaB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.
• Synonyms: ATAR; CD270; HVEA; HVEM; LIGHTR; TR2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction