AIM (CD5L) Rabbit Polyclonal Antibody

CAT#: TA306318

Rabbit Polyclonal AIM Antibody

Product Images

Western blot analysis of AIM in Raji lysate with AIM antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

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  Immunohistochemistry of AIM in human lymph node tissue with AIM antibody at 10 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 10 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: AIM antibody was raised against a 13 amino acid peptide near the carboxy terminus of human AIM.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD5 molecule like
• Database Link:
  NP_005885
  Entrez Gene 11801 MouseEntrez Gene 922 Human
  UniProt ID O43866
• Background: Apoptosis inhibitor of macrophages (AIM) is a member of the scavenger receptor cysteine-rich domain superfamily (SRCR-SF) initially identified as an inducible cell surface ligand of CD5. It was shown that AIM functions in the thymus as the inducer of resistance to apoptosis within CD4+/CD8+ thymocytes and as the supporter of the viability of these cells before thymic selection. AIM was also shown to support macrophage survival and enhance their phagocytic function. More recent experiments using recombinant AIM significantly inhibited apoptosis of NKT and T cells obtained from C. parvum-stimulated livers in vitro, suggesting that AIM functions to induce resistance to apoptosis in these cells and supports host defense against inflammation during infection.
• Synonyms: AIM; API6; PRO229; SP-ALPHA; Spalpha

Reference Data

• Protein Families: Druggable Genome, Secreted Protein