TANK Rabbit Polyclonal Antibody

CAT#: TA306341

Rabbit Polyclonal TANK Antibody

Product Images

Western blot analysis of TANK in Daudi cell lysate with TANK antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

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  Immunohistochemistry of TANK in rat spleen tissue with TANK antibody at 10 ug/ml.

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  Immunofluorescence of TANK in Rat Spleen cells with TANK antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TANK antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human TANK.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: Lot Dependent
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TRAF family member associated NFKB activator
• Database Link:
  NP_004171
  Entrez Gene 21353 MouseEntrez Gene 252961 RatEntrez Gene 10010 Human
  UniProt ID Q92844
• Background: TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. This activation of NF-kappaB occurs through an association with the kinases IKKepsilon and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IkappaB complex. This suggests that in addition to the possibility that TBK1 and IKKepsilon activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappaB proteins. At least two isoforms of TANK are known to exist.
• Synonyms: I-TRAF; ITRAF; TRAF2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: RIG-I-like receptor signaling pathway