Perilipin 3 (PLIN3) Rabbit Polyclonal Antibody

CAT#: TA306344

Rabbit Polyclonal TIP47 Antibody

Product Images

Western blot analysis of TIP47 in EL4 cell lysate with TIP47 antibody at (A) 0.5 and (B) 1 ug/ml.

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  Immunohistochemistry of TIP47 in rat liver tissue with TIP47 antibody at 2 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TIP47 antibody was raised against a 14 amino acid peptide from near the amino terminus of human TIP47.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: perilipin 3
• Database Link:
  NP_001157661
  Entrez Gene 66905 MouseEntrez Gene 316130 RatEntrez Gene 10226 Human
  UniProt ID O60664
• Background: Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.
• Synonyms: M6PRBP1; PP17; TIP47

Reference Data

• Protein Families: Druggable Genome