TRPC6 Rabbit Polyclonal Antibody

CAT#: TA306348

Rabbit Polyclonal TRPC6 Antibody

Product Images

Western blot analysis of TRPC6 in mouse lung tissue lysate with TRPC6 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

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  Immunohistochemistry of TRPC6 in mouse lung tissue with TRPC6 antibody at 10 ug/ml.

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  Immunofluorescence of TRPC6 in Mouse Lung cells with TRPC6 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TRPC6 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human TRPC6.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transient receptor potential cation channel subfamily C member 6
• Database Link:
  NP_004612
  Entrez Gene 22068 MouseEntrez Gene 89823 RatEntrez Gene 7225 Human
  UniProt ID Q9Y210
• Background: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the “canonical TRP” (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types (1). Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.
• Synonyms: FSGS2; TRP6

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane