TRPC3 Rabbit Polyclonal Antibody

CAT#: TA306352

Rabbit Polyclonal TRPC3 Antibody

Product Images

Western blot analysis of TRPC3 in human brain tissue lysate with TRPC3 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of TRPC3 in mouse heart tissue with TRPC3 antibody at 2 ug/ml.

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  Immunofluorescence of TRPC3 in Mouse Heart cells with TRPC3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TRPC3 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human TRPC3.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transient receptor potential cation channel subfamily C member 3
• Database Link:
  NP_001124170
  Entrez Gene 22065 MouseEntrez Gene 60395 RatEntrez Gene 7222 Human
  UniProt ID Q13507
• Background: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the “canonical TRP” (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.
• Synonyms: SCA41; TRP3

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane