IRF7 Rabbit Polyclonal Antibody

CAT#: TA306354

Rabbit Polyclonal IRF7 Antibody

Product Images

Western blot analysis of IRF7 in 293 whole cell lysate with IRF7 antibody at (A) 0.5 and (B) 1 ug/ml.

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  Immunohistochemistry of ?IRF7 in mouse spleen tissue with IRF7 antibody at 5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the center of human IRF7.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interferon regulatory factor 7
• Database Link:
  NP_001563
  Entrez Gene 3665 Human
  UniProt ID Q92985
• Background: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling (3,4). There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
• Synonyms: IMD39; IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway