DDX58 Rabbit Polyclonal Antibody

CAT#: TA306359

Rabbit Polyclonal RIG-1 Antibody

Product Images

Western blot analysis of RIG-1 in C2C12 cell lysate with RIG-1 antibody at (A) 0.5, (B) 1 and (C) 2ug/ml.

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  Immunohistochemistry of RIG-1 in rat heart tissue with RIG-1 Antibody at 10ug/ml.

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  Immunohistochemistry of RIG-1 in human heart tissue with RIG-1 antibody at 5ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RIG-1 antibody was raised against human GST-tagged RIG-1 protein.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: DEXD/H-box helicase 58
• Database Link:
  NP_055129
  Entrez Gene 230073 MouseEntrez Gene 297989 RatEntrez Gene 23586 Human
  UniProt ID O95786
• Background: The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKKepsilon through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
• Synonyms: RIG-I; RIGI; RLR-1

Reference Data

• Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway