GPR44 (PTGDR2) Rabbit Polyclonal Antibody

CAT#: TA306387

Rabbit Polyclonal CRTH2 Antibody


USD 430.00

In Stock*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen CRTH2 antibody was raised against a 18 amino acid peptide from near the amino terminus of human CRTH2.
Formulation PBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name prostaglandin D2 receptor 2
Background The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist.
Synonyms CD294; CRTH2; DL1R; DP2; GPR44
Reference Data
Protein Families Druggable Genome, GPCR, Transmembrane

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