GPR44 (PTGDR2) Rabbit Polyclonal Antibody

CAT#: TA306387

Rabbit Polyclonal CRTH2 Antibody

Product Images

Western blot analysis of CRTH2 in Jurkat cell lysate with CRTH2 antibody at 1 ug/ml in (A) the absence and (B) presence of blocking peptide.

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  Immunohistochemistry of CRTH2 in human heart tissue with CRTH2 antibody at 2.5 ug/ml.

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  Immunofluorescence of CRTH2 in Human Heart tissue with CRTH2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CRTH2 antibody was raised against a 18 amino acid peptide from near the amino terminus of human CRTH2.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: prostaglandin D2 receptor 2
• Database Link:
  NP_004769
  Entrez Gene 14764 MouseEntrez Gene 309212 RatEntrez Gene 11251 Human
  UniProt ID Q9Y5Y4
• Background: The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist.
• Synonyms: CD294; CRTH2; DL1R; DP2; GPR44

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane