PD L2 (PDCD1LG2) Rabbit Polyclonal Antibody

CAT#: TA306402

Rabbit Polyclonal PDL-2 Antibody

Product Images

Western blot analysis of PDL-2 in Raji cell lysate with PDL-2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

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  Immunohistochemistry of PDL-2 in mouse brain tissue with PDL-2 antibody at 2.5 ug/ml.

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  Immunofluorescence of PDL-2 in Mouse Brain cells with PDL-2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PDL-2 antibody was raised against a 16 amino acid peptide from near the center of human PDL-2.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: programmed cell death 1 ligand 2
• Database Link:
  NP_079515
  Entrez Gene 58205 MouseEntrez Gene 309304 RatEntrez Gene 80380 Human
  UniProt ID Q9BQ51
• Background: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1. At least three isoforms of PDL-2 are known to exist; this antibody is specific to the largest isoform. PDL-2 antibody has no cross-reactivity to PDL-2.
• Synonyms: B7DC; bA574F11.2; Btdc; CD273; PD-L2; PDCD1L2; PDL2

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)