Neuritin (NRN1) Rabbit Polyclonal Antibody

CAT#: TA306415

Rabbit Polyclonal Neuritin Antibody

Product Images

Western blot analysis of neuritin in Daudi cell lysate with neuritin antibody at (A) 5 and (B) 10ug/ml.

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  Immunohistochemistry of Neuritin in human brain tissue with Neuritin antibody at 2.5ug/ml.

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  Immunohistochemistry of Neuritin in mouse heart tissue with Neuritin antibody at 5ug/ml.

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  Immunofluorescence of Neuritin in Mouse Heart cells with Neuritin antibody at 20ug/ml.

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  Immunofluorescence of Neuritin in human brain tissue with Neuritin antibody at 20ug/ml.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 5 and 10 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Neuritin antibody was raised against a 20 amino acid synthetic peptide from near the center of human neuritin. The immunogen is located within amino acids 70 - 120 of Neuritin.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: neuritin 1
• Database Link:
  NP_057672
  Entrez Gene 68404 MouseEntrez Gene 51299 Human
  UniProt ID Q9NPD7
• Background: As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.
• Synonyms: dJ380B8.2; NRN