Neurotrypsin (PRSS12) Rabbit Polyclonal Antibody

CAT#: TA306416

Rabbit Polyclonal Neurotrypsin Antibody

Product Images

Western blot analysis of neurotrypsin in SK-N-SH cell lysate with neurotrypsin antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

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  Immunohistochemistry of Neurotrypsin in human brain tissue with Neurotrypsin antibody at 2.5 ug/ml.

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  Immunofluorescence of Neurotrypsin in Human Brain cells with Neurotrypsin antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Neurotrypsin antibody was raised against a 23 amino acid peptide from near the amino terminus of human neurotrypsin.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protease, serine 12
• Database Link:
  NP_003610
  Entrez Gene 19142 MouseEntrez Gene 85266 RatEntrez Gene 8492 Human
  UniProt ID P56730
• Background: Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.
• Synonyms: BSSP-3; BSSP3; MRT1

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein