Huntingtin Associated Protein 1 (HAP1) Rabbit Polyclonal Antibody

CAT#: TA306425

Rabbit Polyclonal HAP1 Antibody

Product Images

Western blot analysis of HAP1 in mouse brain tissue lysate with HAP1 antibody at (A) 0.5 and (B) 1 ug/ml.

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  Immunohistochemistry of HAP1 in human brain tissue with HAP1 antibody at 2.5 ug/ml.

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  Immunofluorescence of HAP1 in Human Brain cells with HAP1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: HAP1 antibody was raised against a 19 amino acid peptide from near the center of human HAP1.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: huntingtin-associated protein 1
• Database Link:
  NP_001073339
  Entrez Gene 15114 MouseEntrez Gene 29430 RatEntrez Gene 9001 Human
  UniProt ID P54257
• Background: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
• Synonyms: HAP2; hHLP1; HIP5; HLP

Reference Data

• Protein Pathways: Huntington's disease