Interferon beta (IFNB1) Rabbit Polyclonal Antibody

CAT#: TA306437

Rabbit Polyclonal IFN-beta Antibody

Product Images

Western blot analysis of IFN-b in A-20 cell lysate with IFN-b antibody at 5ug/ml.

• 

  Immunohistochemistry of IFN-b in human liver tissue with IFN-b antibody at 2.5ug/ml.

• 

  Immunohistochemistry of IFN-b in human liver tissue with IFN-b antibody at 5ug/ml.

• 

  Immunofluorescence of IFN-beta in Human Liver cells with IFN-beta antibody at 20ug/ml.

• 

  Immunofluorescence of IFN-beta in mouse liver tissue with IFN beta antibody at 20ug/ml.

Show all 5 images

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 5 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IFN-beta antibody was raised against a 17 amino acid synthetic peptide from near the center of human IFN-b. The immunogen is located within amino acids 110 - 160 of IFN-beta.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interferon beta 1
• Database Link:
  NP_002167
  Entrez Gene 15977 MouseEntrez Gene 3456 Human
  UniProt ID P01574
• Background: Type I Interferons (IFN-a/b) are produced primarily in response to viral infection by “Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-b binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-b. IFN-b is currently used clinically for treatment of tumors, infections and multiple sclerosis.
• Synonyms: IFB; IFF; IFNB

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway