IEX1 (IER3) Rabbit Polyclonal Antibody

CAT#: TA306438

Rabbit Polyclonal IEX-1 Antibody

Product Images

Western blot analysis of IEX1 in human brain tissue lysate with IEX1 antibody at (A) 2 and (B) 4 ug/ml.

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  Immunohistochemistry of IEX-1 in human liver tissue with IEX-1 antibody at 2.5 ug/ml.

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  Immunofluorescence of IEX-1 in Human Brain cells with IEX-1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 2 - 4 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IEX1 antibody was raised against a 24 amino acid peptide near the center of human IEX1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: immediate early response 3
• Database Link:
  NP_003888
  Entrez Gene 15937 MouseEntrez Gene 8870 Human
  UniProt ID P46695
• Background: IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-a. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappaB/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.
• Synonyms: DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1; PRG1

Reference Data

• Protein Families: Druggable Genome