Slpi Rabbit Polyclonal Antibody

CAT#: TA306440

Rabbit Polyclonal SLPI Antibody

Product Images

Western blot analysis of SLPI in A-20 cell lysate with SLPI antibody at 2 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 2 ug/mL
• Reactivities: Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SLPI antibody was raised against a 17 amino acid peptide from near the center of mouse SLPI.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: secretory leukocyte peptidase inhibitor
• Database Link:
  NP_035544
  Entrez Gene 20568 Mouse
  UniProt ID P97430
• Background: Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kB activation by inhibiting IkB degradation in the cytoplasm and competing for NF-kB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.
• Synonyms: ALK1; ALP; antileukoproteinase; BLPI; HUSI; HUSI-1; HUSI-I; MPI; WAP4; WFDC4