Slpi Rabbit Polyclonal Antibody

CAT#: TA306440

Rabbit Polyclonal SLPI Antibody


USD 430.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications WB
Recommended Dilution WB: 2 ug/mL
Reactivities Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen SLPI antibody was raised against a 17 amino acid peptide from near the center of mouse SLPI.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name secretory leukocyte peptidase inhibitor
Background Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kB activation by inhibiting IkB degradation in the cytoplasm and competing for NF-kB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.
Synonyms ALK1; ALP; antileukoproteinase; BLPI; HUSI; HUSI-1; HUSI-I; MPI; WAP4; WFDC4
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.