STEAP3 Rabbit Polyclonal Antibody

CAT#: TA306465

Rabbit Polyclonal STEAP3 Antibody

Product Images

Western blot analysis of STEAP3 in rat liver tissue lysate with STEAP3 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of STEAP3 in mouse liver tissue with STEAP3 antibody at 2.5 ug/ml.

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  Immunofluorescence of STEAP3 in Mouse Liver cells with STEAP3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: STEAP3 antibody was raised against a 15 amino acid peptide from near the amino terminus of human STEAP3.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: STEAP3 metalloreductase
• Database Link:
  NP_001008410
  Entrez Gene 68428 MouseEntrez Gene 170824 RatEntrez Gene 55240 Human
  UniProt ID Q658P3
• Background: The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP4), STEAP3 promotes both iron and copper reduction. STEAP3 is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, suggesting that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells. This STEAP3 antibody does not cross-react with other STEAP proteins.
• Synonyms: AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3; TSAP6

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: p53 signaling pathway