ARMET (MANF) Rabbit Polyclonal Antibody

CAT#: TA306478

Rabbit Polyclonal MANF Antibody

Product Images

Western blot analysis of MANF in mouse brain tissue lysate with MANF antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of MANF in human brain tissue with MANF antibody at 2.5 ug/ml.

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  Immunofluorescence of MANF in Human Brain cells with MANF antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: MANF antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human MANF.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: mesencephalic astrocyte derived neurotrophic factor
• Database Link:
  NP_006001
  Entrez Gene 74840 MouseEntrez Gene 315989 RatEntrez Gene 7873 Human
  UniProt ID P55145
• Background: MANF, also known as ARMET, was initially identified as a protein containing an arginine-rich region that was highly mutated in a variety of tumors. More recently it was identified as a mesencephalic astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons, similar to glial cell line-derived neurotrophic factor (GDNF) and CDNF. In rat brain slices, MANF enhanced nigral gamma-aminobutyric acid release. Like GDNF and CDNF, MANF has selective neuroprotective activity for dopaminergic neurons suggesting that it may be indicated for the treatment of Parkinson’s disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress. This antibody does not cross-react with CDNF.
• Synonyms: ARMET; ARP

Reference Data

• Protein Families: Druggable Genome, Secreted Protein